Conventional genetic analyses of prions involving rrna sequences are impossible because Prions do not contain nucleic acids
The name "prions" refers to aberrant, pathogenic agents that are transmissible and capable of inducing improper folding of specific normal cellular proteins known as prion proteins, which are abundant in the brain.
Prions are virus-like creatures that contain a prion protein. These elongated fibrils (green) are thought to be protein aggregations from the infectious prion. Prions cause neurodegenerative brain illness by attacking nerve cells. Symptoms of "mad cow" include glassy eyes and uncontrollable bodily trembling.
Prion disorders develop when normal prion protein, which is found on the surface of many cells, becomes aberrant and clumps in the brain, causing harm to the brain.
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Conventional genetic analyses of prions involving rrna sequences are impossible because Prions do not contain nucleic acids.
Prions are misfolded proteins that have the ability to transmit their misfolded shape onto normal variants of the same protein. They characterize several fatal and transmissible neurodegenerative diseases in humans and many other animals. It is not known what causes a normal protein to misfold, but the resulting abnormal three-dimensional structure confers infectious properties by collapsing nearby protein molecules into the same shape.
The word prion is derived from the term, "proteinaceous infectious particle". In comparison to all other known infectious agents such as viroids, viruses, bacteria, fungi, and parasites, all of which contain nucleic acids (DNA, RNA, or both), the hypothesized role of a protein as an infectious agent stands in contrast.
Prion isoforms of the prion protein (PrP), whose specific function is uncertain, are hypothesized as the cause of transmissible spongiform encephalopathies (TSEs), including scrapie in sheep, chronic wasting disease (CWD) in deer, bovine spongiform encephalopathy (BSE) in cattle (commonly known as "mad cow disease") and Creutzfeldt–Jakob disease (CJD) in humans.
All known prion diseases in mammals affect the structure of the brain or other neural tissue; all are progressive, have no known effective treatment, and are always fatal. Until 2015, all known mammalian prion diseases were caused by the prion protein (PrP); however, in 2015 it was hypothesized that multiple system atrophy (MSA) was caused by a prion form of alpha-synuclein.
Prions are a type of intrinsically disordered protein, which change their conformation unless they are bound to a specific partner such as another protein. With a prion, two protein chains are stabilized if one binds to another in the same conformation. The probability of this happening is low, but once it does the combination of the two is very stable. Then more units can get added, making a sort of "fibril". Prions form abnormal aggregates of proteins called amyloids, which accumulate in infected tissue and are associated with tissue damage and cell death. Amyloids are also responsible for several other neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
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_________, which involves severe impairment of memory as part of a loss of intellect and personality, is most closely associated with the deterioration of _________-producing neurons.
Alzheimer's which involves severe impairment of memory as part of a loss of intellect and personality, is most closely associated with the deterioration of ; acetylcholine producing neurons.
As far as dementia goes, Alzheimer's disease is the most prevalent. The disease is gradual, starting with mild memory loss and potentially progressing to the loss of communication and environmental awareness. The brain regions that are responsible for thought, memory, and language are affected by Alzheimer's disease. Age-related changes in the brain as well as genetic, environmental, and lifestyle variables are likely contributing factors. There are less acetylcholine molecules in the brains of those who have Alzheimer's disease. Acetylcholine aids in the communication between certain nerve cells. Some of the acetylcholine-using nerve cells are also lost as a result of Alzheimer's disease.learn more about Alzheimer's here: https://brainly.com/question/18406872
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Does the entire process of glucose breakdown in the body occurs in the presence of oxygen?
The correct option is (b)i.e, false that the entire process of glucose breakdown in the body occurs in the presence of oxygen.
The metabolic process that converts glucose into pyruvic acid is known as glycolysis. The high-energy molecules adenosine triphosphate and reduced nicotinamide adenine dinucleotide are created using the free energy released during this process. A series of ten enzyme-catalyzed processes make up glycolysis.
Another name for glycolysis is the EMP pathway. It is named after Embden, Meyerhof, and Parnas, the names of the discoverers. Because it is the metabolic process by which glucose produces cellular energy, glycolysis is significant. The most crucial source of energy for all living things is glucose. The great majority of cells in the human body chose glucose as their preferred fuel because only red blood cells can utilize it.
Fermentation is a process that allows glycolysis to occur in the absence of oxygen. The citric acid cycle, oxidative phosphorylation, and the other three phases of cellular respiration all require oxygen to function. In the cytoplasm of the cell, glucose is first broken down. This cellular respiration process is anaerobic, which means oxygen is not needed for it to occur.
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What would be a likely outcome if the alignment of maternal and paternal chromosomes durinmg metaphase of meiosis?
A Final statement or concluding statement
Answer: Alleles for genes would tend to be inherited together because chromosome pairs would align non-randomly.
What is meiosis?Meiosis is a type of cell division that results in the production of four gamete cells and a halving of the number of chromosomes in the parent cell. In this, Meiosis I and II, the two cell divisions, occur without the S phase in between. The sister chromatids are held together by a mechanism known as cohesion during meiosis I, where the chromatin condenses like it does during mitosis.
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The hepatic portal vein collects blood from the gi tract and conducts it to the ____.
a. liver
b. hepatic vein
c. heart
d. spleen
Answer:
a.
Explanation:
The portal vein or hepatic portal vein (HPV) is a blood vessel that carries blood from the gastrointestinal tract, gallbladder, pancreas and spleen to the liver.
What does asexual and sexual reproduction have in common?
Require living cells
Produces offspring
Has DNA for genetic information
A food contains 1.1 grams carbohydrates, 13 grams protein, and 11 grams fats. how many calories does the food provide?
The fate of pyruvate produced during glycolysis depends primarily on the availability of.
Molecular oxygen
The fate of pyruvate produced during glycolysis depends primarily on the availability of molecular oxygen.
What is glycolysis?Glycolysis is a cytoplasmic mechanism that converts glucose into two molecules with three carbons each and releases energy. Hexokinase, a phosphorylating enzyme, assists in the phosphorylation process that traps glucose. This reaction uses adenosine triphosphate (ATP), and the end result, glucose-6-P, inhibits hexokinase.What happens during glycolysis?The process by which glucose is broken down to provide energy is known as glycolysis. It generates two pyruvate molecules, ATP, NADH, and water. Importance of glycolysis:Because it is the metabolic process by which glucose produces cellular energy, glycolysis is significant. The most crucial source of energy for all living things is glucose.Most cells in the human body prefer glucose as a fuel because red blood cells cannot use anything else.To learn more about glycolysis visit:
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The ____________ plays a significant role in the icf because phosphates are capable of binding and unbinding h , depending on current conditions of acidity or alkalinity.
The phosphate buffer system plays a significant role in the ICF because phosphates are capable of binding and unbinding H⁺, depending on current conditions of acidity or alkalinity.
What is the role of the phosphate buffer system in ICF?The phosphate buffer system plays an important role in buffering intracellular fluid (ICF).
H₂PO₄⁻ and HPO₄²⁻ are the two primary components of the phosphate buffer system. When a mixture of these two chemicals is exposed to a potent acid, such as HCl, the hydrogen is absorbed by the base HPO₄²⁻ and transformed into H₂PO₄⁻.
The strong acid, HCl, is replaced by another weak acid, NaH₂PO₄, as a result of this reaction, which also minimizes pH reduction.
The OH⁻ is buffered by the H₂PO₄⁻ to create further amounts of HPO₄²⁻ + H₂O when a strong base, such as NaOH, is added to the buffer system.
In this scenario, a strong base (NaOH) is exchanged for a weak base (NaH₂PO₄), leading to a minimal pH increase.
The body fluids' typical pH is 7.4, so the phosphate buffer system's pK of 6.8, which is close to that value, enables the system to function close to its maximal buffering capacity.
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Given the following diagram, what product is produced at Location A?
This diagram shows various processes and products in the global carbon cycle. Location A shows organisms in the ocean undergoing photosynthesis and respiration.
Public Domain
Carbohydrates
Carbonic acid
Fossil fuels
Limestone
When a person overdoses on drugs, ultimately, what brain structure was shut down to produce death?
A Final statement or concluding statement
'Medulla' shuts downs as a result of drug overdose.
Why shutting down of Medulla results in death?Usually, medulla damage results in death. Additionally, morphine (and other opiate medications), cocaine, and amphetamine have a very strong effect on this region. Through the impairment of cardiovascular function, these medicines have the potential to result in drug overdose. The development of apnea and a lessened respiratory response to hypoxia are both brought on by receptors, which also produce a medullary diminished response to hypercarbia.
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Which line depicts the growth of a population of acidophiles in the vaginal tract?
A glycogen-rich vaginal milieu depicts the growth of a population of acidophiles in the vaginal tract.
An efficient initial line of defense against invading pathogens, such as bacterial vaginosis, aerobic vaginitis-associated bacteria, viruses, fungi, and protozoa, is provided by lactobacilli and their antibacterial and anti-inflammatory compounds combined with elements of the epithelial mucosal barrier. Eubiosis and the health of the vagina depend on a healthy host-microbe interaction.
The lactic acid and cytolysin generated by lactobacilli promote glycogen availability and the lysis of epithelial cells. Lactic acid makes the vaginal environment more acidic, which encourages the growth of Lactobacilli while preventing the formation of infection-related organisms.
The bacteria that inhabit the vagina are known as vaginal flora. Several lactobacillus species predominate in the normal vaginal flora. By creating lactic acid, hydrogen peroxide, and other compounds that stop the growth of yeast and other undesirable organisms, lactobacilli contribute to the vagina's overall health.
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What is the name of the irreversible inhibitor (drug) used as an example in the lecture?
Diisopropylfluorophosphate (DPF) is the irreversible inhibitor (drug) used as an example in the lecture. the its an enzyme hydrolyses the pheophrous- Florine bond, but the phosphate remains bound to serine in the active site and deactivating it.
Irreversible inhibitor are contently /non contently bound to the specific enzyme and slow down the enzyme. invisible hibitors are 3 types such as group specific reagents , reactive substrate analogs also known as affinity label and inhibitor.
There are some examples of irreversible inhibitors -compound diisopropylphosphofluoridate (DIPF), nerve gases ,acetylcholinesterase ,and preventing transmission of impulse. Penicillin irreversibly inhibits the enzyme transpeptidase by reacting with transpeptidase.
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Which description is an example of gravitational potential energy transforming into kinetic energy?
A roller coaster is a classic example of conversion of kinetic energy into gravitational potential and gravitational potential into kinetic energy.
What is kinetic energy ?The kinetic energy of an object is the energy that it possesses due to its motion. It is defined as the work needed to accelerate a body of a given mass from rest to its stated velocity. Having gained this energy during its acceleration, the body maintains this kinetic energy unless its speed changes.
What is gravitational potential energy ?Gravitational potential energy is energy an object possesses because of its position in a gravitational field. The most common use of gravitational potential energy is for an object near the surface of the Earth where the gravitational acceleration can be assumed to be constant at about 9.8 m/s2.
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What can be determined by exhaustive methylation of an oligosaccharide with ch3i followed by acid hydrolysis?
Methylation analysis and then hydrolysis are utilized to confirm the new oligosaccharide's glycosidic linkage information.
What is an oligosaccharide?
When two or more monosaccharides bind together via O-glycosidic bonds, oligosaccharides are formed.When compared to other, more prevalent carbohydrates, including those in the disaccharide group, oligosaccharides, or carbohydrates with between 3 and 10 single sugar residues, are not as prevalent in the diet.Examples of oligosaccharides: sucrose, lactose and maltose
What is Exhaustive methylation?Exhaustive methylation is the process of adding methyl groups to an alkyl ring until all methylations are complete. Extensive methylation transforms an amine into an alkylammonium salt prior to E2 elimination in the Hofmann elimination reaction sequence.To learn more about exhaustive methylation visit:
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What does the fossil trace golf course in golden, colorado, have to do with mineral resources?what does the fossil trace golf course in golden, colorado, have to do with mineral resources?
Fossil trace golf course is a prehistoric club with a massive remnants of clay mining equipment can be seen throughout the layout designed by renowned architect Jim Engh.
what is fossil trace golf course?A club with ancient history and remnants of clay mining equipment.
Each piece is of rich history of the property and save the memories of many award winning golf players.
It was established in July 2003 in the Colorado City of Golden which was actually opened 64-million years
Fossil Trace Golf Club is widely called as one of Denver’s top golf course.
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If you do an ames test on a substance and the results show many bacteria colonies growing, what does this indicate?
If in an Ames test the result with many bacteria colonies growing indicates that the chemical that is being tested is a mutagen.
Any physical or chemical agent that has the ability to alter an organism's genetic makeup and result in a mutation is referred to as a mutagen.
The Ames test is a biological experiment used to evaluate a chemical compound's potential for mutagenicity. It makes use of bacteria to examine whether a specific chemical can result in DNA alterations in the test organism. Bruce N. Ames created the test in the 1970s.
A large number of colonies indicates that the chemical has caused alterations in the genetic material of the bacteria. Since cancer is frequently linked to mutation, a positive test result will suggest that the substance is mutagenic and so may serve as a carcinogen but not necessarily.
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What would happen if a mutation occurred in dna such that the second codon of the resulting mrna were changed from ugg to uag?
No functional protein would be produced since translation would halt at the second codon.
Why does mutation occurs in DNA?A sector or patch of cells with defective function can result from a somatic mutation, a change in the DNA of a body cell of a multicellular organism that can be passed on to descendant cells by DNA replication. Any transcriptional or translational mistake may result in mutations occurring spontaneously. Spontaneous mutation is the term used to describe mutations that die on their own without being influenced by their environment.
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name the two parts of an ecosystem from which organisms need resources to survive and reproduce?
Answer:
abiotic and biotic
Explanation:
the abiotic components of any ecosystem are properties os the environment
The axial skeleton contains ________. 1. skull 2. scapula 3. true and false ribs 4. vertebrae 5. phalanges
The axial skeleton contains the skull, true and false ribs, and vertebrae. Option 1 and 4.
What is axial skeleton?The axial skeleton is a portion of the skeleton that consists of the bones of the head, the neck, the chest, and the back.
It is in contrast to the appendicular skeleton which consists of the bones of the upper and lower extreme of the body, including the bones of the shoulder and the pelvis.
The axial skeleton consists of 80 bones altogether, including the bones of the ears and the vertebral column.
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A dihybrid cross produces 30 recombinant offspring out of a total of 1,000 offspring. What is the recombination frequency of the two gene pairs?
The recombination frequency of the two gene pairs is 3%.
The number of recombinant offspring(r.o.) / total number of offspring x 100% = recombination frequency(θ):
r.o./total x 100% = θ
30/100 x 100% = 3%
Recombinant offspring are children that have a different allele combination to their parents.
For example, say a mother has a haploid cell with the alleles AB and the father has a haploid cell with the alleles ab. These combine to make a diploid cell with the sequence Aa+Bb.
Formation of Recombinant Offspring :
Recombination can happen in two different ways; independent assortment and crossing over.
Independent assortment is when the maternal and parental DNA are mixed during meiosis, creating a new gene sequence.Crossing over happens during the first stage of meiosis when the two homologous chromosomes are paired and a portion breaks off on the same loci then reconnects to a different end. Crossing over can only happen when there isn't a physical linkage of the parental alleles.Recombination frequency (θ) is the frequency with which a single chromosomal crossover will take place between two genes during meiosis. A centimorgan (cM) is a unit that describes a recombination frequency of 1%. In this way we can measure the genetic distance between two loci, based upon their recombination frequency. This is a good estimate of the real distance. Double crossovers would turn into no recombination. In this case we cannot tell if crossovers took place. If the loci we're analysing are very close (less than 7 cM) a double crossover is very unlikely. When distances become higher, the likelihood of a double crossover increases. As the likelihood of a double crossover increases we systematically underestimate the genetic distance between two loci.
When two genes are close together on the same chromosome, they do not assort independently and are said to be linked. Whereas genes located on different chromosomes assort independently and have a recombination frequency of 50%, linked genes have a recombination frequency that is less than 50%.
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What is the medical term for the act of belching or raising gas orally from the stomach?
Eructation is the medical term for the act of belching or raising gas orally from the stomach. It is preceding vomiting consists of pronged retching movement during the period of nausea and spasmodic uncoordinated contraction of muscles of respiration during diaphragm contracts.
Passing of gas through the mouth is called as burping. The return of swallowed food to the mouth is known as regurgitation. This is the process to eliminate the gas that is produced as a byproduct of microbial fermentation.
Burping keeps your stomach from expanding too much from swallowed air. That air travels back to esophagus, which leads to an audible release that people it burp.
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Acetyl coa is a feed forward activator of the enzyme ________ ensuring sufficient oxaloacetate for the citric acid cycle to continue.
Acetyl CoA is a feed forward activator of the enzyme pyruvate carboxylase ensuring sufficient oxaloacetate for the citric acid cycle to continue.
Why does acetyl-CoA stimulate pyruvate carboxylase?Acetyl-CoA selectively activates pyruvate carboxylase. When acetyl-CoA concentrations are high, organisms use pyruvate carboxylase to divert pyruvate from the TCA cycle because acetyl-CoA is a crucial metabolite in the TCA cycle that generates a lot of energy. The production of more oxaloacetate is triggered by an excess of mitochondrial acetyl-CoA.
Acetyl coenzyme A, often known as acetyl-CoA, is a crucial component in metabolism and is involved in numerous metabolic processes. Its major job is to transport the acetyl group's carbon atoms to the Krebs cycle, where they can be oxidized to produce energy. When there is an abundance of acetyl CoA available, the mitochondrial enzyme pyruvate carboxylase (PC) catalyzes the conversion of pyruvate to oxaloacetate.
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when evaluating a dorsal decubitus abdomen radiograph, the technologist notices that the iliac crests are superimposed, the pedicles of the lumbar vertebrae are superimposed, and the intervertebral joints are open. what, if any, mistake in positioning has been made
If when evaluating a dorsal decubitus abdomen radiograph, the technologist notices that the iliac crests are superimposed, the pedicles of the lumbar vertebrae are superimposed, and the intervertebral joints are open. No mistake in the positioning has been made.
What is dorsal decubitus abdomen radiograph?Dorsal decubitus abdomen radiograph can be defined as they type of x-ray conducted by sonographer when a patient is lying on the his or her back so as to check and diagnose if the patient as any of the following condition:
Abdominal traumaIatrogenic injury etc.Despite noticing that the iliac crests are superimposed, the pedicles of the lumbar vertebrae are superimposed, and the intervertebral joints are open No mistake has been made in the positioning.
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How does intestinal failure affect the body? carbon dioxide builds up in the body. carbon dioxide builds up in the body. energy is not given to the body. energy is not given to the body. oxygen does not make it to the brain. oxygen does not make it to the brain. blood is not moved in the body.
Answer:
Its energy is not given to body
Explanation:
Intestinal failure is basically like where your intestines is slow and has no energy.
Platelets are pinched off from giant multinucleated cells in the bone marrow called?
When stomata are open and a plant is transpiring normally, how does water move from the soil into the root xylem? select all that apply.
When stomata are open and a plant is transpiring normally, movement of water from the soil into the root xylem is brought about by:-
Pressure generated by roots which pumps water upwards in the plant. Without any additional work done on the fluid by the plant.Evaporation from the leaves in the form of transpiration.In 1895, the Irish plant physiologists H. H. Dixon and J. Joly suggested that water is pulled up the plant by tension or negative pressure from above.
As water is continually being lost from the leaves through transpiration, Dixon and Joly concluded that the loss of water in the leaves exerts a pull on the water in the xylem ducts and draws more water into the leaf.
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The __________ gland is the gland that triggers other glands to release hormones.
The pituitary gland is the gland that triggers other glands to release hormones. It is a pea sized gland attached to the base of the brain. It is important in controlling growth and development and the functioning of the other endocrine glands. Without the pituitary gland, the body wouldn't reproduce, wouldn't grow properly and wouldn't function.
What part of henry’s cochlea may have damaged hair cells? What part of henry’s cochlea may have functional hair cells?
The henry's may have damaged and functional hair cells of cochlea in organ of corti.
Hearing and the Cochlea:
Sound waves that enter the ear go through the external auditory canal before they strike the eardrum and cause it to vibrate. The incus receives sound vibrations from the malleus, also called "hammer," which is linked to the eardrum, and sends them on to the stapes.The stapes is a framework that moves the oval window in and out. This motion is received by the cochlea, a fluid-filled snail-like structure that houses the organ of Corti, the hearing organ. Small hair cells make up the lining of the cochlea. These cells convert vibrations into electrical impulses that sensory nerves then transmit to the brain. the Corti organ, which has four rows of hair cells. On the left, there is an inner row, and on the right, there are three outside rows. The stapes first sways against the oblong glass. This causes sound waves to travel into the cochlear fluid and move the organ of Corti.Lower frequency sound resonates with fibers towards the cochlea's upper end. Higher frequencies elicit a response from those near the oval window.Learn more about the Structure of ear with the help of the given link:
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There are approximately 4 to 11 ____________ white blood cells per microliter of blood.
There are approximately 4,500 to 11,000 WBCs white blood cells per microliter of blood.
The immune system of the body includes white blood cells. They support the body's defenses against illness and infection.Granulocytes (neutrophils, eosinophils, and basophils), monocytes, and lymphocytes are different types of white blood cells (T cells and B cells).Blood typically contains 4,500 to 11,000 WBCs per microliter (4.5 to 11.0 109/L), or WBCs. Different labs may have slightly different normal value ranges. Some laboratories may test various specimens or utilize various metrics. Discuss your test results with your provider.Too many white blood cells typically indicate an infection or inflammatory condition within the body. A high white blood cell count may, less frequently, be a sign of some blood malignancies or bone marrow issues.learn more about white blood cells here: https://brainly.com/question/87658
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Alpha helices are a type of secondary structure in proteins. What is the length of a 37.0 kda single‑stranded α‑helical protein segment?
The protein having 37kda has 336.36 amino acids long, roughly making single-stranded alpha-helix 93.43 turns, giving it a rise in 504.4 Â (Armstrong).
A secondary structure component, an alpha helix, has an amino acid chain organised in a spiral. The following characteristics describe the perfect alpha helix:
It is a right-handed helix that completes one turn every 3.6 residues, rises by about 5.4 with each turn, and is often somewhat curved.Hydrogen bonds hold it together between the C=O of residue I and the NH of residue I+4.The (phi, psi) angles of all residues involved in an alpha-helix are comparable. These angles, around -60 and -50, are taken from the Ramachandran plot's bottom left quadrant.To learn more about alpha-helix click here
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