1. A cell must continuously sort useful materials from its waste products and then remove or recycle the waste. One way a cell does this is to first put tiny tags on proteins that are no longer needed. These tags, which are small polypeptide chains 76 amino acids long, are called ubiquitin.

2. Ubiquitin tags direct proteins to compartments of the cell called proteasomes. Within each proteasome, ubiquitin-tagged proteins are deconstructed into their component amino acids. These pieces can be repurposed to build new proteins.

3. Sometimes organs stop processing waste effectively, allowing the waste to pile up and contributing to many diseases. Alzheimer's disease, for example, includes piles of waste proteins in the brain called tangles, while Parkinson's disease involves the accumulation of recyclable material into Lewy bodies. Mallory bodies are piles of waste proteins common in liver disease. These piles, known generically as inclusions, can be identified under the microscope because they are covered in tiny ubiquitin tags.

4. A problem in the breakdown of ubiquitin-tagged proteins may be one cause of spinocerebellar ataxia type 1. In this disease, a protein called ataxin-1 has an abnormal genetic mutation, and ubiquitin is able to attach to the mutant protein. Scientists believe that the mutated protein cannot be chopped up by the proteasome because of its shape, so ubiquitin-tagged ataxin-1 starts to accumulate, which leads to cell death. The cells most affected by this genetic mutation are neurons in a part of the brain associated with motor control and the spinal cord. So, a person with mutant ataxin-1 progressively loses muscle control as these cells die.


Which phrase describes the purpose of ubiguitin

A. to tag waste proteins for recycling in the proteasomes

B. to create small polypeptide chains that are 76 amino acids long

C. to create inclusions that can be identified under the microscope

D. to attach to mutant proteins so that they can accumulate In the cell


If proteins contain mutations, the proteins often do not maintain the proper shape and are unable to perform their functions. Properly functioning proteins are essential to maintaining healthy organisms.

Which statement describes the overall consequence of proteins containing mutations like those described in the passage?

A. Wastes will build up and will be reassembled to build new proteins.

B. Wastes will build up, and Mallory bodies will accumulate in the liver.

C. Wastes will build up in cells and will eventually be excreted from each cell.

D. Wastes will build up in vital organs, and the organism will experience disease.


Why do individuals with spinocerebellar ataxia experience loss of muscle control, even though the ataxin-1 protein builds up only In the brain and spinal cord?

A. Inclusions can build up in all body systems and can cause debilitating effects.

B. Genetic mutations in the ataxin-1 protein cause muscular proteins to change shape.

C. When the ubiquitin tagging system does not work effectively, cellular waste can build up in the muscles.

D. The neurons affected by the ataxin-1 protein buildup are in a region of the brain that manages muscle control.

Answers

Answer 1

Based on the role of ubiquitin in protein deconstruction as stated in the passage, the correct options are as follows:

to tag waste proteins for recycling in the proteasomes; option A.Wastes will build up in vital organs, and the organism will experience disease; option Dthe neurons affected by the ataxin-1 protein buildup are in a region of the brain that manages muscle control; option D.

What are phrases?

Phrases refers to a group of words which contains a verb but which on their own do not make complete sense.

In the description of the role of Ubiquitin, it is described as a small polypeptide chain containing 76 amino acids. The main tole of ubiquitin is to tag proteins for deconstruction in the proteasomes.

Therefore, the phrase describes the purpose of ubiquitin is to tag waste proteins for recycling in the proteasomes; option A.

Based on the passage, the statement that describes the overall consequence of proteins containing mutations is: Wastes will build up in vital organs, and the organism will experience disease; option D

Individuals with spinocerebellar ataxia experience loss of muscle control, even though the ataxin-1 protein builds up only in the brain and spinal cord because the neurons affected by the ataxin-1 protein buildup are in a region of the brain that manages muscle control; option D.

In conclusion, mutations in ubiquitin-tagged proteins will result in accumulation in the body since they cannot be deconstructed in the proteasomes.

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Related Questions

The volume of a gas at 0 degrees Celsius is 100 L. If the volume of the gas is increased to 200 L at a constant temperature, what is the new temperature of the gas in Kelvin?

Answers

The new temperature of the gas in Kelvin, given the data from the question is 273 °C

Data obtained from the question

From the question given above, the following data were obtained:

Initial volume (V₁) = 100 LInitial temperature (T₁) = 0 °C = 0 + 273 = 273 KPressure = ConstantNew volume (V₂) = 200 LNew temperature (T₂) =?

How to determine the new temperature

The new temperature of the gas can be obtained by using the Charles' law equation as illustrated below:

V₁ / T₁ = V₂ / T₂

100 / 273 = 200 / T₂

Cross multiply

100 × T₂ = 273 × 200

Divide both side by 100

T₂ = (273 × 200) / 100

T₂ = 546 K

Subtract 273 to obtain answer in °C

T₂ = 546 – 273 K

T₂ = 273 °C

Thus, new temperature of the gas is 273 °C

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If the value for ΔS is postive, and the value for ΔH is negative, thr reaction will be
Group of answer choices

A. spontaneous at high temperatures.

B. spontaneous at all temperatures.

C. spontaneous at low temperatures.

D. Δnot spontaneous at all temperatures.

Answers

It follows that the reaction is spontaneous at high temperatures Option A.

What is ΔS ?

The term ΔS is referred to as the change in the entropy of the system. Now recall that entropy is defined as the degree of disorderliness in a system. If a system is highly disorderly then it means that it has a high entropy. Also, ΔH has to do with the heat change that accompanies a reaction.

We know that both the entropy and the heat change can both either be positive or negative. Now we know that the equation ΔG = ΔH - TΔS can be used to ascertain whether or not a reaction will be spontaneous. If the result is negative, then the reaction will be spontaneous.

As such, when then it follows that the reaction is spontaneous at high temperatures Option A.

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What is the oxidation number of nitrogen in nitrogen gas?
Group of answer choices

A. -2

B. -1

C. -3

D. 0

Answers

Ans: (D) 0
Hope my answer is correct:))

What volume, in liters, of 0.023 M NH4NO3 solution can be made using 25 g NH4NO3
The molar mass of NH4NO3 is 80.043 g/mol

Answers

Answer:

14 L

Explanation:

To find the volume, you need to (1) convert grams to moles (via molar mass) and then (2) calculate the volume (via molarity equation). The final answer should have 2 sig figs to match the sig figs of the given values.

(Step 1)

Molar Mass (NH₄NO₃): 80.043 g/mol

 25 grams NH₄NO₃                 1 mole
-------------------------------  x  -------------------------  =  0.312 moles NH₄NO₃
                                           80.043 grams

(Step 2)

Molarity = moles / volume

0.023 M = 0.312 moles / volume                <----- Insert values

(0.023 M) x volume = 0.312 moles             <----- Multiply both sides by volume

volume = 14 L                                               <----- Divide both sides by 0.023

Volume, in liters, of 0.023 M NH₄NO₃ solution can be made using 25 g NH₄NO₃ are 13.47L.

What is Molarity?

Molarity of a given solution is known as the total number of moles of solute per litre of the solution.  A solution that is 1.00 molar (written 1.00 M) contains 1.00 mole of solute for every liter of solution.

Molarity = (No. of moles of solute ÷ Volume of solution in liters)

The unit of molarity is mol L⁻¹.

Molarity is temperature dependent because as temperature changes, volume of the solution also changes.

No. of moles of solute = Mass / Molar mass

No. of moles of solute = 0.31

Hence,

Volume of solution in liters = No. of moles of solute ÷ molarity

= 13.47 litres

Therefore, Volume, in liters, of 0.023 M NH₄NO₃ solution can be made using 25 g NH₄NO₃ are 13.47L.

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In the reaction between CO and Fe3O4 , the theoretical yield in an experiment is calculated to be 47.2 g Fe.

When a chemistry student carries out the experiment, their actual yield is 34.1 g Fe.

Calculate the percent yield (% yield) of Fe

Answers

Answer:

Explanation:

34.1 / 47.2 x 100%   =   0.07%

The percent yield (% yield) of Fe in a reaction with CO if the theoretical yield in the experiment is calculated to be 47.2 g Fe is 72.25%.

How to calculate percent yield?

The percent yield is the percent ratio of the weight of the product obtained to the theoretical yield.

The percent yield can be calculated by dividing the experimental yield by the theoretical yield and multiplying the result by 100 then express the final answer in %.

According to this question, the experimental yield is 34.1g and the theoretical yield is 47.2g. The percent yield can be calculated as follows:

Percent yield = 34.1/47.2 × 100

Percent yield = 72.25%

Therefore, the percent yield (% yield) of Fe in a reaction with CO if the theoretical yield in the experiment is calculated to be 47.2 g Fe is 72.25%.

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Oliver and Mike put some ice into a container and heat it .​

Answers

Answer:

See below

Explanation:

From the graph: initial temp = -10 ° C

    melting occurs at 0 ° C   (constant temp process)

     at '2'   the ice is melting.....going from a solid to a liquid at a constant temperature  

Consider the following reaction at 298K.
I2 (s) + H2 (g) 2 I- (aq) + 2 H+ (aq)

Which of the following statements are correct?

Answers

From the forgoing, we can conclude that the the correct statements are;

n = 2 mol of electronsK < 1What are the redox reaction?

The redox reaction is one in which one specie is oxidized and the other is reduced. We can obtain the equilibrium constant from the relation;

E°cell = 0.0592/n log K

E°cell = cell potential

n = number of electrons

K = equilibrium constant

E°cell = -0.403 - 0.535 = -0.938 V

n = 2 electrons

Thus;

-0.938 =  0.0592/2 logK

-0.938 * 2/ 0.0592 = log K

K = 2 * 10^-31

Also;

ΔG = - nFE°cell

ΔG = - (2 * 96500 *  -0.938)

ΔG = 181kJ/mol

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What volume did a helium-filled balloon have at 22.5 c and 1.95 atm if it’s new volume was 56.4 mL at 3.69 atm and 11.9c

Answers

This is an exercise in the general or combined gas law.

To start solving this exercise, we obtain the following data:

Data:T₁ = 22.5 °C + 273 = 295.5 KP₁ = 1.95 atmV₁ = ¿?P₂ = 3.69 atmT₂ = 11.9 °C + 273 =  284.9 kV₂= 56.4 ml

We use the following formula:

P₁V₁T₂ = P₂V₂T₁ ⇒ General formula

Where

P₁ = Initial pressureV₁ = Initial volumeT₂ = Initial temperatureP₂ = Final pressureV₂ = final volumeT₁ = Initial temperature

We clear the formula for the initial volume:

[tex]\boldsymbol{\sf{V_{1}=\dfrac{P_{2}V_{2}T_{1}}{P_{1}T_{2}} } }[/tex]

We substitute our data into the formula to solve:

[tex]\boldsymbol{\sf{V_{1}=\dfrac{(3.69 \not{atm})(56.4 \ ml)(295.5 \not{k})}{(1.95 \not{atm})(284.9\not{k})} }}[/tex]

[tex]\boldsymbol{\sf{V_{1}=\dfrac{61498.278}{555.555} \ lm }}[/tex]

[tex]\boxed{\boldsymbol{\sf{V_{1}=110.697 \ lm }}}[/tex]

The helium-filled balloon has a volume of 110.697 ml.

Answer:

111  ml

Explanation:

Use the general rule for gases:

P1 V1 / T1    =   P2 V2 / T2      Looking for V1     T must be in Kelvin

re-arrange to :

V1 =   P2 V 2  * T1 / (T2 * P1)      <==== now sub in the values

V1 = 3.69 * 56.4 * (22.5 + 273.15) / [(11.9 + 273.15) * 1.95]

V1 = 110.6949 ml

    for correctness, the answer should only have THREE significant digits as all of the factors have three SD

V1 = 111 ml

perform the following operation and express the answer in scientific notation 6x10^2 / 8x10^12

Answers

Answer:

7.5 x 10 ^-11

Explanation:

6/8 = .75

10^2 / 10^12   = 10^ (2-12) = 10^(-10)

so far    .75  x 10^-10  

    which is   7.5 x 10^-11

If you dilute a solution what is the only thing about the solution that does NOT change?
Group of answer choices

A. Concentration

B. Kilograms of Solvent

C. Moles of Solute

D. Liters of Solution

Answers

Taking into account the definition of dilution, moles of solute (option C) is the only thing about the solution that does NOT change.

Dilution

When it is desired to prepare a less concentrated solution from a more concentrated one, it is called dilution.

Dilution is the process of reducing the concentration of solute in solution, which is accomplished by simply adding more solvent to the solution at the same amount of solute.

In a dilution the amount of solute does not change, but as more solvent is added, the concentration of the solute decreases, as the volume (and weight) of the solution increases.

A dilution is mathematically expressed as:

Ci×Vi = Cf×Vf

where

Ci: initial concentrationVi: initial volumeCf: final concentrationVf: final volume

Summary

In summary, moles of solute (option C) is the only thing about the solution that does NOT change.

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Which Inorganic Substance has a melting point of -101°C and a boiling point of -35°C?
Group of answer choices

A. Chlorine

B. Hydrogen

C. Hydrogen Sulfide

D. Hydrogen Chloride

Answers

The inorganic substance that has a melting point of -101°C and a boiling point of -35°C is chlorine (option A).

What is melting and boiling point?

Melting point is the temperature at which the solid and liquid phases of a substance are in equilibrium.

On the other hand, the boiling point is the temperature at which a liquid boils, with the vapor pressure equal to the given external pressure.

Chemical elements and compounds have specific boiling and melting points that distinguishes them chemically.

The following are the melting and boiling point of the given compound and elements respectively;

Chlorine - -101°C and -35°CHydrogen: -259.2°C and -252.9 °CHydrogen sulfide: -85.5 °C and -60°CHydrogen chloride: -114.2 °C and - 85°C

Therefore, the inorganic substance that has a melting point of -101°C and a boiling point of -35°C is chlorine.

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Consider this reaction: 6 CO2 + 6 H2O + light equation C6H12O6 + 6 O2 If there were 2.38 x 102 g of H2O, 18.6 moles of CO2, and plenty of light, which reactant would be the limiting reactant?

Answers

H₂O would be the limiting reactant.

Balanced chemical equation:

6CO₂ + 6H₂O + light equation → C₆H₁₂O₆ + 6O₂

The amount of product that can be created is constrained by the reactant that is consumed first in a chemical reaction, commonly referred to as the limiting reactant (or limiting reagent).

Given

No. of moles of CO₂ = 18.6

Mass of H₂O = 2.38 × 10² g = 238g

No. of moles of H₂O = Given mass/ Molar mass

                                = 238 / 18 = 13.22 moles

Moles of H₂O = 13.22

According to the balanced chemical equation

6 moles of CO₂ react with 6 moles of H₂O

So the reactant that has less number of moles will be consumed first.

As the No. of moles of H₂O < No. of moles of CO₂

So, H₂O is the limiting reactant with 13.22 moles.

Hence, H₂O would be the limiting reactant.

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What answer should be reported, with the correct number of significant figures, for the following calculation? (433.621 - 333.9) × 11.900

Answers

Answer:

1187   ( four   S.D. )

Explanation:

(433.621 - 333.9) × 11.900         333.9 has only 4 S.D.      answer should only have 4 S.D

= 1186.6799 = ~  1187     with 4 Significant Digits

HELP NOW pls will give points due soon

Answers

Sorry for the sloppy writing I tried my best.

If you can't read the words in my photo it says

Evaporation

condensation precipitation and runoff

definition of these words

evaporation: The process of turning liquid into vapor

Condensation:water which collects as droplets on a cold surface when humid air is in contact with

Precipitation: the action or process of precipitating a substance from a solution

runoff: liquid, especially water or rainwater, that flows off or drains away

I hope this is helpful

Sincerely- Your Brainly Bestfriend

What is the [OH-] if the [H3O+] is 1 x 10 -6?

Answers

The answer is [OH⁻] = 1 x 10⁻⁸.

To find OH⁻, divide the ionic product of water by [H₃O⁺] as :

OH⁻ + H₃O⁺ = H₂O

[OH⁻] = 1 x 10⁻¹⁴ / 1 x 10⁻⁶[OH⁻] = 1 x 10⁻⁸

Given similar concentrations, the stronger acid corresponds to the lower pH. Comment on the relative strengths of the acids H3PO4, H2PO4^– and H2PO4^2–

Answers

Answer:

H3PO4 is stronger than H2PO4- because

H3PO4 dissociation constant is 6.9×10^-3

H2PO4^- dissociation constant is 6.2×10^-8

How many moles of solute particles are present in 1 mL (exact) of aqueous 0.0040 M Ba(OH)2?

Answers

Answer:

4.0  x 10^-6 moles

Explanation:

0.0040 M Ba(OH)2      means there is .0040 moles per liter

    you want 1 ml which is 1/1000 liter so you get 1/1000 of the moles

= .0000040 moles

How do scientists believe that chloroplasts got into photosynthetic cells? ​

Answers

Let's see what I can come up with here. So chloroplasts are made up of several separate sections. They have the stroma (the liquid in which everything is contained) and the grana (plural of granum and is a stack of thylakoids). Chlorophyll is found in thylakoids.

The chlorophyll absorbs light (not green light since that is what is reflected to our eyes). Light energy is utilized to split water into hydrogen ions, electrons, and oxygen gas. With these ions and electrons, the electron transport chain, with the assistance of enzymes, produces ATP and NADPH. In all living cells, ATP is the primary source of energy. Because light is required to split water, this step of photosynthesis is known as the "light reaction."

The ATP and NADPH are transported into the stroma, where the "dark reaction" can take place. And, despite the name, it does not occur at night since our energy source does not store well. You've probably heard of the Calvin Cycle. The Calvin Cycle basically uses water, CO2, and the energy from earlier to generate carbohydrates, which are then stored in various ways. Glucose is the most well-known monosaccharide, although there are others, as well as countless polysaccharides such as cellulose and starch.

Thank you,

Eddie

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